Neurobiology of Disease Neutralization of Transthyretin Reverses the Neuroprotective Effects of Secreted Amyloid Precursor Protein (APP) in APPSw Mice Resulting in Tau Phosphorylation and Loss of Hippocampal Neurons: Support for the Amyloid Hypothesis
نویسندگان
چکیده
Thor D. Stein,1 Nicholas J. Anders,2 Charles DeCarli,5 Sic L. Chan,6 Mark P. Mattson,6 and Jeffrey A. Johnson1,2,3,4 1Neuroscience Training Program, 2School of Pharmacy, 3Environmental Toxicology Center, and 4Waisman Center, University of Wisconsin, Madison, Wisconsin 53705, 5Department of Neurology and Center for Neuroscience, University of California Davis, Sacramento, California 95817, and 6Laboratory of Neurosciences, Gerontology Research Center, National Institute on Aging, Baltimore, Maryland 21224
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